Inhibition by rupatadine of PAF-induced mortality in mice and of endotoxin-induced mortality in mice and rats
| Compound | ID50 (mg/kg) Against Mortality Induced by PAF in Mice | ID50 (mg/kg) Against Mortality Induced by Endotoxin in | ||
|---|---|---|---|---|
| Mice | Rats | |||
| i.v. | p.o. | i.v. | i.v. | |
| Rupatadine | 0.31 (0.21–0.46) | 3.0 (2.5–3.6) | 1.6 (1.4–1.8) | 0.66 (0.50–0.88) |
| WEB-2086 | 0.084 (0.042–0.17) | 0.97 (0.38–2.5) | 1.9 (1.4–2.6) | 0.47 (0.28–0.78) |
| SCH-37370 | 1.11 (0.93–1.32) | 31 (18–53) | >10 | >5 |
| Loratadine | >3 | >30 | >10 | >5 |
Compounds were administered i.v. 5 min or p.o. 60 min before the administration of 100 μg/kg i.v. C18-PAF plus 1 mg/kg i.v. propanolol or 20 mg/kg i.v. lipopolysaccharide from E. coliserotype 0111:B4 (mice) or 5 mg/kg i.v. lipopolysaccharide fromE. coli serotype 0127:B8 (rats). Mortality was recorded 2 h and 7 days after the administration of PAF and of lipopolysaccharides (endotoxins), respectively. ID50 values were obtained by linear regression from an experimental curve with 4 to 6 data points, each point being the percentage inhibition of mortality at a given dose obtained from a group of 10 animals. Values in parentheses are 95% confidence limits.