Table 1

Monoamine and metabolite levels 1 week after METH treatment

Levels
DADOPACHVA5-HT5-HIAA
μg/g wet weight
Dorsal striatum
 Saline14.2  ± 1.44.6  ± 0.32.02  ± 0.410.26  ± 0.030.98  ± 0.08
 METH8.4  ± 1.0** 3.0  ± 0.4* 0.78  ± 0.06** 0.10  ± 0.02** 0.65  ± 0.09*
Ventral striatum
 Saline11.0  ± 1.04.6  ± 0.22.53  ± 0.420.38  ± 0.041.49  ± 0.16
 METH3.6  ± 0.7** 1.9  ± 0.5** 0.75  ± 0.12** 0.18  ± 0.03** 1.07  ± 0.15
NAc
 Saline6.4  ± 0.63.8  ± 0.31.81  ± 0.300.61  ± 0.081.62  ± 0.12
 METH4.4  ± 0.4* 2.4  ± 0.2** 0.85  ± 0.09** 0.33  ± 0.06* 1.37  ± 0.18
Substantia nigra
 Saline0.79  ± 0.070.46  ± 0.050.17  ± 0.021.04  ± 0.051.59  ± 0.13
 METH0.68  ± 0.020.40  ± 0.080.14  ± 0.010.87  ± 0.071.69  ± 0.12

Values are mean ± S.E.M. for six saline-treated animals and seven METH-treated animals.

  • * P < .05 vs. saline-treated group (two-tailedt test).

  • ** P < .01 vs. saline-treated group (two-tailedt test).