Discriminative stimulus effects of zolpidem, administered i.g., in rats trained to discriminate pentobarbital (8.0 mg/kg i.p.) from saline (1.0 ml/kg i.p.)
| Drug2-aDose | Mean Drug Lever2-b (Range) | Rate-Mean (Range) | Rats Responding/Total Rats Tested2-c |
|---|---|---|---|
| mg/kg i.g. | % | responses/s | |
| Saline | 0.00 | 1.3 | 4 /4 |
| (0.00–0.00) | (0.91–1.7) | ||
| Pentobarbital | |||
| 4.0 | 25.0 | 1.3 | 4 /4 |
| (0.00–100) | (1.1–1.6) | ||
| 8.0 | 97.0 | 1.2 | 4 /4 |
| (88.0–100) | (0.79–1.6) | ||
| 16 | 96.0 | 0.81 | 4 /4 |
| (84.0–100) | (0.48–1.4) | ||
| Zolpidem | |||
| 1.0 | 25.0 | 0.91 | 4 /4 |
| (0.00–100) | (0.070–1.3) | ||
| 2.0 | 45.0 | 1.3 | 4 /4 |
| (0.00–100) | (1.1–1.6) | ||
| 4.0 | 56.0 | 0.61 | 8 /8 |
| (0.100–100) | (0.090–1.6) | ||
| 6.0 | 100 | 0.15 | 2 /7 |
| (100–100) | (0.00–0.66) |
↵2-a Saline, pentobarbital and zolpidem were administered i.g. via gavage 15 min before the session.
↵2-b Percent drug lever data were calculated only from rats responding, whereas rate data were calculated from all rats tested.
↵2-c “Rats responding” was defined as rats completing at least one FR 10 during a test session.