Effects of raloxifene on serum cholesterol and food consumption: paired-feeding studies
| Group | Food Intake | Weight Change | Serum Cholesterol |
|---|---|---|---|
| g/day | g | mg/dl | |
| Control | 18.8 ± 0.8 | −17 ± 1 | 102 ± 15 |
| Raloxifene (1 mg/kg/day) | 13.1 ± 0.9* | −37 ± 3* | 29 ± 6* |
| Pair-fed control | 12.3 ± 0.9* | −51 ± 6* | 97 ± 9 |
Rats were administered raloxifene or vehicle (20% cyclodextrin) once daily for 7 days. Serum cholesterol was determined as described in “Methods.” Pair-fed animals were provided an amount of food identical to that consumed, on average, by the raloxifene-treated group on the previous day of the study. Food intake was determined daily for each group; average values for the entire study period are reported. Serum cholesterol values and body weights were determined at the beginning and end of the study. Base-line serum cholesterol was determined using blood samples obtained from the retroorbital sinus under light anesthesia with CO2. Terminal blood samples were obtained by cardiac puncture. Significant changes in serum cholesterol values from day 0 to day 7 occurred only in the raloxifene-treated group; consequently, only day 7 cholesterol values are reported here. Results are mean ± SEM of five or six rats per group, except for food intake, which was averaged over time.
* P < .05 vs. control group.