TABLE 3
Histomorphometric indices at the lumbar vertebrae (L3) acquired by ex vivo micro computed tomography (micro CT) in sham-OVX and OVX mice after 56 days of treatment with vehicle or anti-DKK1 antibody RH2-18
Representative micro CT slice images by vBMD from respective control and RH2-18 treatment groups.
| Treatment | Intact | OVX | |||
|---|---|---|---|---|---|
| Vehicle | Vehicle | RH2-18 | RH2-18 | ||
| 2 mg/kg | 20 mg/kg | ||||
| Lumbar vertebra | vBMD (mg/cm3) | 248.20 ± 0.70.804*** | 187.20 ± 6.207 | 214.00 ± 8.023 | 258.70 ± 9.514*** |
| BV/TV (%) | 0.161 ± 0.0088* | 0.134 ± 0.0064 | 0.152 ± 0.0058 | 0.184 ± 0.0097*** | |
| TbTh (mm) | 0.023 ± 0.0006*** | 0.019 ± 0.0005 | 0.023 ± 0.0004*** | 0.022 ± 0.0005*** | |
| TbN (no./mm) | 7.044 ± 0.3874 | 7.037 ± 0.3782 | 6.739 ± 0.2434 | 8.278 ± 0.3689 | |
| TbSp (mm) | 0.124 ± 0.0080 | 0.127 ± 0.0070 | 0.128 ± 0.0054 | 0.101 ± 0.0055* | |
 | |||||
TbN, trabecular number; TbSp, trabecular spacing.
Data are given as mean ± S.E. One-way analysis of variance, Dunnett's test versus OVX vehicle (*, p < 0.05; ***, p < 0.001).