Effects of acute treatment with PDE4 inhibitors on immobility in the forced-swim test
Values shown are means ± S.E. for times of immobility of separate groups of rats tested in the forced-swim test; n = 6 per group. Rats were treated with PDE4 inhibitors and tested in forced-swim test 0.5 or 2 h post-treatment.
| Immobility | ||
|---|---|---|
| 0.5 h Post-Treatment | 2 h Post-Treatment | |
| s | ||
| Vehicle | 154 ± 10.2 | 138 ± 14.2 |
| Rolipram | 84 ± 12.1* | 144 ± 7.4 |
| 0.3 mg/kg | 174 ± 9.2 | 122 ± 7.0 |
| 1 mg/kg | ||
| 3 mg/kg | 201 ± 8.6 | 127 ± 10.9 |
| Piclamilast | 58 ± 6.24** | 132 ± 5.9 |
| 0.3 mg/kg | ||
| 1 mg/kg | ||
| 3 mg/kg | 129 ± 25.4 | 123 ± 9.3 |
| CDP840 | 91 ± 6.5* | 141 ± 10.6 |
| 3 mg/kg | 122 ± 19.0 | 126 ± 12.5 |
| 10 mg/kg | ||
| 30 mg/kg | 125 ± 15.0 | 123 ± 6.1 |
↵** P < 0.01; *P < 0.05 vs. corresponding control.