TABLE 7

Estimated parameters for the agonist concentration-response curves shown in Fig. 7

Agonist	Estimated Parameters
Agonist	Log K_a	Log RI_i^{^a}	Log RA_i^{^a}	Log K_obs	Relative τ^{^b}
Oxotremorine-M	N.D.	N.D.	2.01	5.46	1.00
Oxotremorine	5.96	0.74	1.77	6.02	0.16
Carbachol	5.17	−0.05	1.43	5.31	0.37
Arecoline	5.44	0.22	1.37	5.51	0.20
S-Aceclidine	5.35	0.13	1.13	5.40	0.15
Pilocarpine	5.54	0.32	0.75	5.55	0.044
R-Aceclidine	5.01	−0.21	0.38	5.03	0.063
Bethanechol	4.09	−1.13	0.27	4.21	0.32
McN-A-343	5.22	0.00	0.00	5.23	0.017

N.D., not determined.
↵a Expressed relative to that of McN-A-343.
↵b Expressed relative to that of oxotremorine-M.