Saline | PZ03 | PZ10 | PZ30 | PZ56 | PZ100 | |
---|---|---|---|---|---|---|
Placebo saline | 41.5 (39.5, 44.3) | 32.5 (29.8, 35.0)* | 18.5 (16.8, 19.3)* | 2.0 (0.0, 3.3)* | 0.5 (0.0, 2.0)* | 0.0 (0.0, 0.3)* |
C-CAM | 42.0 (39.5, 43.3) | 42.5 (40.3, 45.0)# | 41.5 (38.8, 42.5)# | 41.0 (38.0, 42.8)# | 20.5 (16.0, 24.3)*# | 27.5 (18.3, 31.5)*# |
nor-BNI | 42.0 (39.8, 45.3) | 32.5 (30.8, 35.3)* | 18.5 (16.8, 21.0)* | 2.0 (0.0, 6.5)* | 1.0 (0.0, 3.5)* | 0.0 (0.0, 0.3)* |
C-CAM + nor-BNI | 42.0 (39.0, 43.3) | 41.5 (40.8, 42.8)# | 41.5 (40.5, 42.5)# | 41.0 (40.3, 42.5)# | 43.5 (40.8, 50.3)# | 42.5 (40.5, 45.3)# |
↵* P < 0.05 compared with saline as a placebo for pentazocine by Mann-Whitney test, indicating significant antinociceptive effects to visceral pain of pentazocine.
↵# P < 0.05 compared with mice pretreated with saline (as a placebo for C-CAM and/or nor-BNI) by Mann-Whitney test, indicating significant antagonism by the opioid receptor antagonists.