Pharmacokinetic parameters for fasudil and hydroxyfasudil in mice after an intraperitoneal administration of fasudil
Values represent mean (n = 4).
| Parameters | Fasudil | Hydroxyfasudil | ||
|---|---|---|---|---|
| 3 mg/kg | 10 mg/kg | 3 mg/kg | 10 mg/kg | |
| AUC (ng ยท h/ml) | 109.7 | 384.2 | 423.8 | 1522.9 |
| Cmax (ng/ml) | 454.0 | 1499.0 | 452.4 | 2014.5 |
| Tmax (min) | 5.0 | 5.0 | 10.0 | 10.0 |
| T1/2 (min) | 12.8 | 9.3 | 51.4 | 36.4 |