ChE activity: heritability and association analysis
Trait heritability (H2r) and the associated P values and covariate P values are displayed for blood ChE activities, AChE and BChE, in the San Diego twin study. Genetic and environmental factors that contribute to the blood ChE heritability are listed (in boldface: P < 0.05). Heritability is the fraction of trait variance accounted for by additive genetic variance (h2 = VG/VP), estimated by variance components in the SOLAR package. Mean ± S.E.M. is the confidence interval for heritability. The P value column is the significance of the trait heritability estimate (initially considered in isolation; top row for each trait). The covariate P value is the significance of a particular covariate (in that row) for effects on additive genetic variance of that trait.
| SOLAR Heritability Analysis: San Diego Caucasian Twins ChE Activity | |||||
|---|---|---|---|---|---|
| Trait/Covariate | H2r | H2r S.E.M. | P Value | Covariate P Value | n |
| AChE | 0.4883 | 0.0610 | 9.35 × 10−11 | 364 | |
| BP status | 0.4873 | 0.0609 | 8.91 × 10−11 | 0.0791 | 364 |
| SBP (mm Hg) | 0.4784 | 0.0642 | 1.13 × 10−9 | 0.0193 | 343 |
| ACHE SNP-13 P561R | 0.5465 | 0.0737 | 2.42 × 10−8 | 0.0126 | 274 |
| ACHE SNP-16 3′-UTR | 0.6114 | 0.0638 | 1.57 × 10−10 | 0.0811 | 287 |
| ACHE haplotype 1 | 0.4775 | 0.0623 | 3.31 × 10−10 | 0.0394 | 362 |
| ACHE diplotype 2/4 | 0.4851 | 0.0618 | 1.68 × 10−10 | 0.0129 | 362 |
| ACHE diplotype 2/7 | 0.4763 | 0.0626 | 4.08 × 10−10 | 0.0514 | 361 |
| BChE | 0.814 | 0.0279 | 1.09 × 10−32 | 364 | |
| Age (years) | 0.8061 | 0.0292 | 4.37 × 10−31 | 0.0031 | 364 |
| Weight (kg) | 0.8015 | 0.0298 | 1.25 × 10−30 | 6.21 × 10−9 | 364 |
| Height (cm) | 0.8097 | 0.0286 | 7.91 × 10−32 | 0.0278 | 364 |
| SBP (mm Hg) | 0.8067 | 0.0311 | 1.63 × 10−26 | 0.0331 | 343 |
| BMI (kg/mg2) | 0.7921 | 0.0312 | 1.45 × 10−29 | 4.96 × 10−12 | 364 |
| BCHE SNP-1 intron-2 | 0.7822 | 0.0206 | 2.79 × 10−31 | 0.0021 | 423 |
| BCHE SNP-2 3′-UTR | 0.7894 | 0.0299 | 9.1 × 10−32 | 0.0322 | 420 |
BP status, hypertensive/normotensive; ACHE SNP13, rs1799806; ACHE SNP16, rs17228616; BCHE SNP1, rs1355534 (intron-2); BCHE SNP2, rs3495 (3′-UTR); ACHE diplotype 2/4, diploid haplotype composed of ACHE haplotypes 2 and 4; ACHE diplotype 2/7, diploid haplotype composed of ACHE haplotypes 2 and 7.