Effect of GSK1016790A (10 μM) on TRPV4+/+ and TRPV4−/− bladder pressures (mm Hg) and volumes (μl)
| Pressure | Volume | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Threshold | Peak | Average | Minimal | Infused | Void | |||||||
| Control | 790A | Control | 790A | Control | 790A | Control | 790A | Control | 790A | Control | 790A | |
| mm Hg | μl | |||||||||||
| TRPV4+/+(n = 8) | 13.0 ± 0.5 | 15.3 ± 1.8 | 32 ± 3 | 33 ± 2 | 10.3 ± 0.6 | 13.6 ± 1.8 | 6.6 ± 0.6 | 10.1 ± 1.5* | 148 ± 21 | 60 ± 18* | 102 ± 18 | 25 ± 11* |
| TRPV4−/− (n = 3) | 9.9 ± 1.9 | 9.8 ± 1.7 | 28 ± 3 | 28 ± 3 | 8.4 ± 1.4 | 7.5 ± 1.1 | 3.8 ± 0.8 | 3.5 ± 0.3 | 255 ± 16 | 280 ± 29 | 250 ± 18 | 287 ± 36 |
790A, GSK1016790A.
↵* P < 0.05 vs. same genotype control, paired t test.