TABLE 2

Effects of PST3093 (0.22 mg.kg⁻¹.min⁻¹), istaroxime (0.22 mg.kg⁻¹.min⁻¹), and digoxin (0.11 mg.kg⁻¹.min⁻¹) on echo indexes of STZ rats at 15 minutes of infusion Data are the mean ± S.E.M.

Echo Parameters		Istaroxime		PST3093		Digoxin
Echo Parameters		Before	At 15 Min	Before	At 15 Min	Before	At 15 Min
Morphometric Parameters	IVSTd (mm)	1.91 ± 0.09	1.97 ± 0.16	1.89 ± 0.09	1.86 ± 0.11	1.79 ± 0.07	1.81 ± 0.04
	PWTd (mm)	1.6 ± 0.07	1.68 ± 0.09	1.46 ± 0.05	1.47 ± 0.07	1.71 ± 0.08	1.66 ± 0.1
	LVEDD (mm)	7.25 ± 0.15	7.1 ± 0.2	7.22 ± 0.17	7.57 ± 0.17	6.76 ± 0.15	6.67 ± 0.15
	IVSTs (mm)	2.4 ± 0.1	2.45 ± 0.12	2.16 ± 0.11	2.31 ± 0.13	2.25 ± 0.14	2.31 ± 0.1
	PWTs (mm)	2.33 ± 0.16	2.42 ± 0.15	2.43 ± 0.12	2.62 ± 0.14	2.47 ± 0.16	2.68 ± 0.14
	LVESD (mm)	3.82 ± 0.21	3.8 ± 0.2	3.89 ± 0.18	3.66 ± 0.15	3.53 ± 0.17	3.14 ± 0.14^a
Systolic Parameters	FS (%)	47.21 ± 2.4	46.72 ± 2.1	46.2 ± 2.02	51.8 ± 1.89^a	47.62 ± 1.9	53.09 ± 1.8^a
	s′ (mm/s)	23.37 ± 0.9	23.05 ± 0.7	22.0 ± 0.72	23.4 ± 0.5^a	23.5 ± 0.9	26 ± 1.5^a
	EF (%)	83 ± 2	82 ± 62	82 ± 1.9	87 ± 1.5^a	84 ± 1.5	88 ± 1.3^a
Diastolic Parameters	E (mm/s)	0.91 ± 0.04	0.94 ± 0.04	0.91 ± 0.06	1.05 ± 0.07^a	0.831 ± 0.03	0.924 ± 0.06
	A (mm/s)	0.66 ± 0.04	0.78 ± 0.05^a	0.79 ± 0.08	0.87 ± 0.07	0.59 ± 0.05	0.79 ± 0.05^a
	E/A	1.39 ± 0.06	1.22 ± 0.08	1.18 ± 0.05	1.22 ± 0.04	1.48 ± 0.11	1.2 ± 0.06^a
	DT (ms)	46.62 ± 4.1	34.12 ± 2.5^a	48.5 ± 3.8	40.2 ± 3.0	53.4 ± 3.8	44.1 ± 3.2^a
	DT/E	51.91 ± 4.9	36.66 ± 3.3^a	56.7 ± 6.5	40.39 ± 4.8^a	65.21 ± 5.3	50.18 ± 5.4^a
	E/DT	21.28 ± 3.2	28.98 ± 2.8^a	20.61 ± 3.0	27.51 ± 2.6^a	16.53 ± 1.7	22.66 ± 3.0
	e′ (mm/s)	21.23 ± 0.99	24.73 ± 0.61^a	22.94 ± 1.0	27.01 ± 1.1^a	20.9 ± 0.5	23.8 ± 0.9^a
	a′ (mm/s)	27.61 ± 1.9	31.35 ± 1.5^a	28.72 ± 2.2	31.06 ± 1.5	25.9 ± 1.9	29.8 ± 1.9
	e′/a′	0.78 ± 0.04	0.79 ± 0.03	0.83 ± 0.06	0.88 ± 0.04	0.85 ± 0.06	0.82 ± 0.04
	E/e′	43.6 ± 2.6	38.29 ± 1.6^a	39.5 ± 1.7	38.61 ± 1.5	39.64 ± 0.9	38.95 ± 2.3
Cardiac Function	HR (bpm)	266.2 ± 9.8	316.2 ± 7.5^a	270 ± 17	271 ± 10	236 ± 12	257 ± 11
	SV (ml)	0.71 ± 0.04	0.67 ± 0.05	0.702 ± 0.05	0.847 ± 0.06^a	0.589 ± 0.03	0.601 ± 0.04
	CO (ml/min)	188.8 ± 10.5	211.2 ± 13.2^a	187.7 ± 13.7	231.7 ± 20.2^a	138.5 ± 11.2	155.6 ± 14.4
	N	8	8	10	10	10	10

^aP < 0.05 versus before drug infusion (paired t test).