Noncompartmental PK parameter estimates after IV administration
| Dose(mg/kg) | N | Cmax(ng/mL) | λz(hr−1) | t1/2(hr) | CL(L/hr/kg) | V(L/kg) | AUC∞/Dose (ng/mL*hr/(ng/kg)) × 10−5 |
|---|---|---|---|---|---|---|---|
| 1 | 2(1) | 425–1340 | 7.2–8.1(3.6) | 0.09–0.10(0.2) | 16.0–20.1(7.2) | 2.0–2.7(2.0) | 49.8–62.5(139.8) |
| 2 | 3(1) | 1654–5287 | 1.2–4.0(1.8) | 0.19–0.56(0.4) | 7.4–13.7(3.4) | 2.6–6.0(1.9) | 72.9–134.8(295.8) |
| 3 | 2 | 2440–4661 | 2.1–2.3 | 0.31–0.33 | 7.9–9.5 | 3.5–4.5 | 105.6–126.3 |
| 4 | 2 | 3660–5172 | 1.4–1.7 | 0.40–0.50 | 6.0–9.9 | 4.2–5.6 | 100.8–167.9 |
Estimates are presented as a range. Values in parentheses are from one dog on chronic PB. Cmax, maximum observed plasma concentration; λz, terminal rate constant; t1/2, terminal half-life; CL, clearance; V, volume of distribution; AUC∞/Dose, dose-normalized area under the concentration-time curve from time 0 extrapolated to infinity.