TABLE 5

Measured and predicted mGlu₅ RO for mavoglurant, dipraglurant, and basimglurant. ub, unbound

Compound	Species	Dose	mGlu₅ RO Measured	mGlu₅ RO Predicted from [plasma]ub	mGlu₅ RO Predicted from [brain]ub
		Rat: mg/kg Human: mg	%
Mavoglurant	Rat	3	45 ± 4	85	64
		10	73 ± 2	95	86
		30	83 ± 3	98	95
Basimglurant	Rat	N/A	50^a	41	36
	Human	0.5	25	27	30
	Human	1.5	53	51	56
Dipraglurant	Human	100	27 ± 9	66	43
		200	44 ± 23	80	60
		300	54 ± 30	85	69