TABLE 3

PK parameters after intravenous bolus administration

Rat: PK studies were conducted in male Sprague-Dawley rats, and PK parameters were determined by analyzing compound concentration-time curves using a noncompartmental curve stripping method. Doses are milligrams free base per kilogram body weight. Values are means ± S.D.

Peptide	Dose	Elimination Half-Life	Clearance	Vc	n
	mg/kg	min (h)	ml/kg per minute	ml/kg
hGLP-2	1.0^{^a}	6.4 ± 0.2 (0.1)	25 ± 2.3	85 ± 15	4
Teduglutide	0.2^{^b}	19 ± 1.9 (0.3)	9.9 ± 2.1	92 ± 31	15
Glepaglutide	0.2^{^b}	16 ± 0.8 (0.3)	2.8 ± 0.4	44 ± 5	3
Apraglutide	0.2^{^b}	159 ± 27 (2.7)	0.27 ± 0.04	63 ± 2	3

↵^a Dosed as single compound.
↵^b Dosed in cassette mode. Cassettes were prepared with three to six peptides per cassette.