TABLE 1

Mean (S.E.M.) binding affinities (Ki, nM) of ubrogepant for human and nonhuman CGRP receptorsa

SpeciesHuman ClonedHuman SK-N-MCRhesusRatMouseRabbitDog
Binding affinity0.07 ± 0.0060.067 ± 0.0040.079 ± 0.0059.6 ± 1.111.6 ± 1.111.0 ± 0.547.0 ± 4.0

  • SK-N-MC, human neuroblastoma cell line.

  • ↵a n = 3–19.