Differentially expressed genes in the Itch Nppb population
Top 20 differentially expressed genes compared with all other sequenced primary afferent populations. Log fold change represents the log 2-fold change for each gene, Score represents the z-score from P value calculation, and P value was adjusted using the Benjamini-Hochberg method (https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1382-0).
| Gene | Log Fold Change | Score | P Value |
|---|---|---|---|
| Nts | 7.6 | 17.5 | 1.3E−36 |
| Sst | 7.9 | 15.5 | 1.3E−30 |
| Il31ra | 7.5 | 15.1 | 3E−29 |
| Ada | 5.7 | 13.7 | 2.1E−26 |
| Osmr | 5.3 | 13.6 | 3.5E−27 |
| Jak1 | 3.9 | 13.4 | 1.1E−28 |
| Nppb | 7.4 | 12.8 | 2.1E−23 |
| Fam210b | 4.2 | 12.3 | 5.9E−23 |
| Pxmp2 | 3.1 | 12.0 | 1.3E−23 |
| Htr1f | 5.2 | 11.9 | 6.4E−22 |
| Npy2r | 5.5 | 11.6 | 1.3E−20 |
| Tesc | 3.4 | 11.4 | 4.6E−22 |
| Adk | 3.5 | 11.2 | 2.9E−21 |
| 9230105E05Rik | 10.5 | 11.2 | 1.1E−18 |
| Mical1 | 3.6 | 11.1 | 5.5E−21 |
| Scg2 | 3.6 | 11.1 | 5.2E−21 |
| Htr1a | 4.7 | 11.0 | 2.1E−19 |
| Cmtm7 | 4.7 | 10.7 | 1.6E−18 |
| Tspan8 | 3.7 | 10.5 | 3.4E−19 |
| Gm525 | 6.8 | 10.4 | 1E−16 |