TABLE 2

Summary of the effects of the tested compounds on neurotransmitter efflux

AChDA5-HTNEDOPACHVA5-HIAASerGlyGluGABA
NAC
 Cariprazine 0.03 mg/kg———————————
 Cariprazine 0.1 mg/kg—III————I——
 Cariprazine 0.3 mg/kg—I—I————II—
 (+)-PD-128907 0.03 mg/kg———————————
 SB-277011A 10 mg/kg—I—IIII—II—
 (+)-PD-128907+SB-277011A 0.03 mg/kg+10 mg/kg—I—————————
 (+)-PD-128907+cariprazine 0.03 mg/kg+0.1 mg/kg———————————
HIP
 Cariprazine 0.03 mg/kg———————————
 Cariprazine 0.1 mg/kg—II—II—————
 Cariprazine 0.3 mg/kg—I—II——————
 (+)-PD-128907 0.03 mg/kg———D———————
 SB-277011A 10 mg/kgII—IIII———D
 (+)-PD-128907+SB-277011A 0.03 mg/kg+10 mg/kgII———I—————
 (+)-PD-128907+cariprazine 0.03 mg/kg+0.1 mg/kg———————————

  • D, decrease; I, increase; —, no effect.