TABLE 3

Best-fit PK/PD model parameters

ParameterDescription%CVMean95% CI
kaAdsorption rate202.5 1/h1.5–3.6 1/h
VVolume of distribution8.90.92 l/kg0.76–1.1 l/kg
CLClearance2.90.075 l/h/kg 0.071–0.079 l/h/kg
kinSEP synthesis rate9.618 µg/l/h 14–21 µg/l/h
koutBaseline rate of SEP conversion to BH42614 1/h7.0–22 1/h
IC50Concentration at half-maximal inhibition292.2 µM0.89–3.5 µM
  • CL, clearance; %CV, percent coefficient of variation.