TABLE 1

Biochemical assessment of SPR inhibition with recombinant rat and human SPR protein

A minimum of three replicates were used to determine the mean and S.D. for each inhibitor.

InhibitorRat SPR IC50Human SPR IC50Human SPR (Reference)
µMµMµM
Sulfasalazine0.100 ± 0.0460.016 ± 0.0040.031 (Yang et al., 2015)
SPRi30.014 ± 0.0070.062 ± 0.0210.074 (Latremoliere et al., 2015)
Q-11950.004 ± 0.0010.008 ± 0.0010.002 (Tebbe et al., 2017)
  • SPRi3, N-(2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl)-2-methoxyacetamide.