Drug potencies in immunosuppression-related luciferase reporter assays
| Lymphocyte Stimulation | NFAT–Luc CsA IC50 (nM) | NFAT–Luc CRV431 IC50 (nM) | NFAT–Luc IC50 Fold Difference | IL-2–Luc CsA IC50 (nM) | IL-2–Luc CRV431 IC50 (nM) | IL-2–Luc IC50 Fold Difference |
|---|---|---|---|---|---|---|
| PMA + A23187 | 3.4 | 204.6 | 60.2 | 8.1 | 300.3 | 36.9 |
| CD3 + CD28 antibodies | 4.5 | 292.2 | 65.4 | 9.0 | 311.5 | 34.6 |