Pharmacokinetic parameters of sulfasalazine and effects of concomitant treatment with hypouricemic agents in Sprague-Dawley rats
Pharmacokinetic parameters were calculated using Phoenix WinNonlin. F values were calculated using the following equation: F = (AUC0–inf value of oral administration/20)/(AUC0–inf value of intravenous administration/5) × 100. Values are reported as the mean ± S.D. of three to four animals.
| Test Article | Dose | Cmax | T1/2 | AUCo–t | AUCinf | CLT | F |
|---|---|---|---|---|---|---|---|
| mg/kg | ng/ml | hours | ng⋅h/ml | ng⋅hours/ml | ml/hours/kg | % | |
| 0.5% MC | — | 422 ± 182 | 1.49 ± 0.28 | 665 ± 94 | 713 ± 90 | 28,395 ± 3800 | 2.0 |
| Febuxostat | 20 | 3138** ± 272 | 1.30 ± 0.13 | 5004** ± 851 | 5012** ± 848 | 4067** ± 607 | 14.1 |
| Benzbromarone | 50 | 1520** ± 202 | 1.24 ± 0.46 | 2858** ± 750 | 2888** ± 729 | 7294** ± 1989 | 8.1 |
| Dotinurad | 1.3 | 415 ± 68 | 1.88 ± 1.56 | 708 ± 166 | 885 ± 264 | 24,126 ± 7777 | 2.5 |
AUCinf, area under the plasma concentration-time curve from zero to infinity; AUC0–t, AUC at 0–12 hours; CLT, total clearance; F, bioavailability; MC, methylcellulose; T1/2, elimination half-life.
↵** P < 0.01, significant differences from the 0.5% MC control group, as analyzed by Dunnett’s multiple comparison test.