MA-induced change in body temperature relative to saline-treated mice
Data represent change (ΔT) in temperature (mean ± S.E.M.) for each treatment group from saline-treated mice at the specified time point; n = 11–12 mice per genotype per treatment group. Taar1 WT saline-treated group body temperature at each timepoint (mean ± S.E.M.): 1st inj, 37.9 ± 0.1°C; 2nd inj, 37.7 ± 0.1°C; 3rd inj, 37.3 ± 0.1°C; 4th inj, 37.1 ± 0.1°C. Taar1 KO saline-treated group body temperature at each timepoint: 1st inj, 37.7 ± 0.2°C; 2nd inj, 37.6 ± 0.1°C; 3rd inj, 37.2 ± 0.1°C; 4th inj, 36.7 ± 0.1°C.
| Genotype | MA Dose (mg/kg) | 30 Min Post-Injection (ΔT °C ± S.E.M.) | |||
|---|---|---|---|---|---|
| 1st Inj | 2nd Inj | 3rd Inj | 4th Inj | ||
| Taar1 WT | 5 | −2.0 ± 0.2* | −0.7 ± 0.3** | −0.1 ± 0.2 | −0.3 ± 0.2 |
| Taar1 KO | 5 | −0.2 ± 0.2 | 0.5 ± 0.1** | 0.3 ± 0.2 | −0.2 ± 0.2 |