Examples of stimuli-responsive release from scaffolds for regenerative medicine
| Drug-Eluting Medical Device | Triggered Stimulus | Reference |
|---|---|---|
| NSAID-immobilized hydrogel coating | Inflammation; overexpression of esterases triggers the release of indomethacin | He et al. (2017) |
| NSAID-immobilized electrospun fibers | Inflammation; overexpression of lipase triggers the release of ibuprofen | Pan et al. (2015) |
| Fibrin scaffolds containing drug-loaded sonosensitive emulsion droplets | Ultrasound; each droplet releases the drug at specific acoustic pressure | Moncion et al. (2018) |
| Fibrin scaffolds containing bFGF encapsulated in monodispersed emulsion droplets | In vivo ultrasound triggered release of the growth factor for efficient angiogenesis | Moncion et al. (2017) |
| Chondroitin sulfate-platelet lysate hydrogel encapsulating magnetic nanoparticles and stem cells | Magnetic field modulates the release of platelet lysate growth factors and, in turn, the tendon- and bone-like matrix synthesis | Silva et al. (2018) |
| Poly(ethylene glycol) hydrogels cross-linked with metalloproteinase substrates and loaded with angiogenic peptide drugs | Cell-released metalloproteinases for regulation of in vivo angiogenesis | Van Hove et al. (2015) |
| Fibrin scaffold with heparin-binding growth factors | Cell-produced heparinase for triggering bFGF release and enhancing peripheral nerve regeneration | Sakiyama-Elbert and Hubbell (2000) |
bFGF, basic fibroblast growth factor; NSAIDs, nonsteroidal anti-inflammatory drugs.