Summary of recent hydrogel technologies applied in drug delivery

InsulinMethyl β-cyclodextrin in polymethacrylic acid (PMAA)Improve intestinal transport upon oral deliverySajeesh et al. (2010)
InsulinHydroxyethyl methacrylate (HEMA)“do”Wang et al. (2018)
InsulinCarboxymethyl cellulose/poly(acrylic acid)“do”Gao et al. (2014)
Insulin and porcine growth hormoneTerpolymer hydrogels P((MAA-co-NVP)-g-EG) composed of methacrylic acid (MAA), N-vinyl pyrrolidone (NVP), and poly(ethylene glycol) (PEG)“do”O’Connor et al. (2017)
DexamethasoneGuar gum (GG), poly(acrylic acid) (PAA) and cyclodextrin (CD) and tetraethyl orthosilicate as linkerEnhanced drug deliveryDas and Subuddhi (2015)
Salmon calcitoninpoly(itaconic acid-grafted-poly(ethylene glycol)) (P(IA-g-EG))Improve intestinal transport upon oral deliveryKoetting and Peppas (2014)
Hematological factor IX hFIXpoly(methacrylic acid)-grafted-poly(ethylene glycol) (P(MAA-g-EG)) (P(MAA-g-EG))Improve intestinal transport upon oral deliveryHorava et al. (2016)
LidocaineChitosan with catechols and genipin cross linkerRapid onset of action via buccal routeXu et al. (2015)
PropranololCarboxymethyl cellulose and ZnO nanoparticles using Fe3+ ion as a crosslinking agentEnhanced drug deliveryZare-Akbari et al. (2016)