Summary of various advanced tablet technologies

Adapted and Modified from Moodley et al. (2012), Choonara et al. (2014).

DrugTechnologyDesignFactors Affecting Drug ReleaseAdvantagesReference
Venlafaxine hydrochlorideProciseDrug core with a holeCore geometryZero-order kinetics or drug release according to core geometryMalewar et al. (2015)
DiltiazemGeomatrixMultilayer tabletPolymer type, thickness of layerZero-order kinetics and controlled drug releaseWilding et al. (1995)
IndomethacinSmartrixMultilayer tablet with specific shape of core layerPolymer type, shape of core layerZero-order kinetics or drug release according to shape of core layerOmer et al. (2017)
MethylphenidateSodas (spheroidal oral drug absorption system)Multilayer tabletLayer thickness, shape of core layerPulsatile drug releaseBiederman et al. (2003)
NorfloxacinDome matrixDome-shaped swellable matrix modulePolymer used, module arrangementDrug release based on module arrangementOliveira et al. (2011)
Fenofibrate captopril, glipizide, and nifedipine3D printed tabletsFabrication through 3D inkjet printing or an extrusion-based or fused deposition modellingPolymer used, drug usedImmediate or controlled releaseKhaled et al. (2015); Kyobula et al. (2017)
Insulin, camostat mesilateChronotropicMultilayer tabletPolymer layers“Two pulse” release and controlled releaseDel Curto et al. (2011)
HeparinGIPETPermeation enhancement technologyPolymer layer, medium fatty acid chainsImmediate or modified releaseLeonard et al. (2006)
CalcitoninPeptelligencePermeation enhancement technologyPolymer layers, a permeation enhancer and the main excipient citric acidImmediate or modified releaseBinkley et al. (2012)
Insulin, lactuloseCODESMultilayer tabletPolymer layers, pH-based releaseImmediate or controlled releaseKatsuma et al. (2004)