Different TRP ion channel–dependent toxicity of silica nanoparticles and PAMAM dendrimers
Results of the cytotoxicity assay show PAMAM G4-NH2 dendrimers and 500-nm MSNPs have different toxicity in TRPA1- and TRPM2-overexpressed HEK-293 cells. Overexpressing of TRPM8 also changed the toxicity of Stöber 50-nm SNPs and 500-nm MSNPs.
| HEK-293 | Nanoparticles |
|---|---|
| Overexpressed TRPV4 channels | No difference in toxicity for any nanoparticles |
| Overexpressed TRPA1 channels | Decreased toxicity for PAMAM G4-NH2 dendrimer and mesoporous SNP 500 nm |
| Overexpressed TRPM2 channels | Decreased toxicity for PAMAM G4-NH2 dendrimer and mesoporous SNP 500 nm |
| Overexpressed TRPM8 channels | Increased toxicity for Stöber SNP 50 nm and mesoporous SNP 500 nm |