Cabotegravir–glucuronide steady-state pharmacokinetic parameters in single-pass perfused livers from male Sprague–Dawley rats
Biliary as well as perfusate excretion rates were calculated between 27.5 and 60 minutes at steady-state (S.S.) conditions, i.e., when these rates reached plateaus. Mean ± S.E.M., n = 3.
| Pharmacokinetic Parameters | Mean ± S.E.M. |
|---|---|
| Biliary recovery (nmol) | 79 ± 17 |
| Perfusate recovery (nmol) | 89 ± 38 |
| S.S. biliary excretion rate (nmol/min) | 1.9 ± 0.4 |
| S.S. perfusate excretion rate (nmol/min) | 2.3 ± 0.9 |
| S.S. liver concentration (nmol/ml) | 41 ± 17 |
| S.S. canalicular clearance (ml/min per kilogram) | 0.16 ± 0.06 |
| S.S. basolateral clearance (ml/min per kilogram) | 0.21 ± 0.12 |