TABLE 2

REF values for transporters involved in hepatic and renal disposition of cabotegravir–glucuronide

REF values for OATs were calculated as expression ratio in HEK293-overexpressing and pooled human kidney samples determined by quantitative proteomics. Protein quantification was based on all identified peptides for the respective protein. REF values for MRPs were calculated as the expression ratio in MRP-overexpressing vesicles and pooled human liver samples (Hepatic REF) or pooled human kidney samples (Renal REF) determined by dot blot. ND, transporter not detected in that tissue. Geometric mean, n = 6; see Supplemental Table 1 for variability on Log₂-transformed REF values.