TABLE 3

Plasma metabolic parameters in SCO-267–treated DIO rats

*P < 0.025 vs. vehicle by one-tailed Williams’ test. n = 6, mean ± S.D.

DosageGlucoseTriglycerideTotal CholesterolAlanine AminotransferaseAspartate Aminotransferase
mg/dlmg/dlmg/dlU/lU/l
Vehicle119 ± 10296 ± 98117 ± 1742 ± 874 ± 29
SCO-267 (0.3 mg/kg)120 ± 2271 ± 63109 ± 848 ± 1561 ± 13
SCO-267 (1 mg/kg)116 ± 14242 ± 75100 ± 12*45 ± 1064 ± 10
SCO-267 (3 mg/kg)118 ± 9261 ± 106102 ± 10*47 ± 862 ± 8