TABLE 2

In vitro plasma protein binding ratios of SCO-267 in rats, dogs, and humans

The mean of three samples is presented. Matrices shown are pooled plasma samples of 20 male Sprague-Dawley rats (8 weeks old), pooled plasma samples of 10 male beagles (10 months old), and pooled plasma samples of 10 male and 10 female humans.

MatrixConcentration of CompoundsBinding Ratio
μg/ml%
Rat0.0599.6
0.599.6
599.6
Dog0.0599.6
0.599.7
599.7
Human0.0599.7
0.599.7
599.7