TABLE 1

Ca2+ influx activity in human FFAR1-expressing CHO cells

Test MaterialCHO Cells with High FFAR1 Expression (Clone 104)CHO Cells with Low FFAR1 Expression (Clone 2)
EC50 [95% CI]Emax (%γ-Linolenic Acid)EC50 [95% CI]Emax (%γ-Linolenic Acid)
nmol/lnmol/l
SCO-2671.3 [0.97–1.7]12512 [11–14]201
AM-16387.1 [5.6–9.2]110150 [120–180]182
Fasiglifam24 [16–37]100>1,00022
α-Linolenic acid>10,000110>10,00093
Linoleic acid>10,000109>10,000102
Palmitic acid>10,000113>10,00078
γ-Linolenic acid>10,000100>10,000100
  • CI, confidence interval.