Residence time at the human M2 and M3 receptors, expressed as half-life (t1/2)
Results are expressed as the mean ± S.E.M. of two independent experiments.
| Compound | t1/2, h | t1/2 Ratio | |
|---|---|---|---|
| M2 | M3 | M3/M2 | |
| AZD8871 | 0.46 ± 0.06 | 4.97 ± 0.36 | 10.8 |
| Batefenterol | 0.07 ± 0.03 | 0.16 ± 0.02 | 2.3 |
| Tiotropium | 1.31 ± 0.47 | 16.04 ± 1.58 | 12.2 |
| Glycopyrrolate | 0.07 ± 0.01 | 2.6 ± 0.14 | 37.1 |
| Ipratropium | 0.04 ± 0.01 | 0.18 ± 0.04 | 4.5 |