PIP3 levels in induced sputum following single and repeat dosing
| Dose | Time Point | Ratio of Adjusted Geometric Mean (90% CI) vs. Placebo | Reduction in PIP3 proportion | Probability (ratio <1) |
|---|---|---|---|---|
| µg | h | % | % | |
| Part A | ||||
| 50 | 3 | 0.75 (0.64, 0.88) | 25 | 99.8 |
| 24 | 0.93 (0.78, 1.10) | 7 | 76.8 | |
| 100 | 3 | 0.88 (0.76, 1.03) | 12 | 90.5 |
| 24 | 0.97 (0.82, 1.15) | 3 | 59.8 | |
| 200 | 3 | 0.71 (0.61, 0.84) | 29 | 100 |
| 24 | 0.98 (0.83, 1.17) | 2 | 56.7 | |
| 500 | 3 | 0.72 (0.61, 0.84) | 28 | 100 |
| 24 | 1.07 (0.90, 1.28) | −7 | 26.1 | |
| 1000 | 3 | 0.76 (0.64, 0.89) | 24 | 99.7 |
| 24 | 0.88 (0.73, 1.06) | 12 | 86.7 | |
| 2000 | 3 | 0.73 (0.63, 0.85) | 27 | 99.9 |
| 24 | 0.95 (0.81, 1.13) | 5 | 68.1 | |
| Part B | ||||
| 2000 | 3 (day 1) | 0.62 (0.44, 0.89) | 38a | 98.3 |
| 2000 | 3 (day 12) | 0.80 (0.67, 0.97) | 20a | 96.9 |
| 24 (day 12) | 1.03 (0.77, 1.38) | −3a | 42 |
↵a Placebo corrected values.