Potency of compounds in human or rat whole blood
Whole-blood potency IC50 (nanomolar).
| Biomarker | MSD-496486311 | MSD-126796721 | Idelalisib | Duvelisib |
|---|---|---|---|---|
| Human pAKT (in vitro) | 42 | 1534 | 90 | 112 |
| Rat CD63 (in vitro) | 1200 | 4800 | 800 | 500 |
| Rat CD63 (ex vivo) | 300 | 1200 | 490 | 96 |