Effects of isoflurane on neuronal Nav subtype recovery from fast inactivation
Data are expressed as means ± S.D. Numbers in parentheses are the percentage change compared with the control.
| Subtype | τrecovery, Vh −100 mV | τrecovery, Vh −70 mV | ||||
|---|---|---|---|---|---|---|
| CTL | ISO | Δ | CTL | ISO | Δ | |
| ms | ||||||
| Nav1.1 | 1.6 ± 0.2 | 1.9 ± 0.3** | 0.3 ± 0.2 (16) | 6.1 ± 0.8*** | 7.4 ± 1.2** | 1.3 ± 0.7 (21) |
| Nav1.2 | 1.9 ± 0.5* | 2.2 ± 0.6** | 0.3 ± 0.2 (17) | 8.4 ± 2.4*,*** | 10.1 ± 2.9** | 1.7 ± 0.8 (20) |
| Nav1.6 | 1.2 ± 0.2* | 1.7 ± 0.2** | 0.4 ± 0.3 (38) | 4.7 ± 0.7* | 6.6 ± 1.0** | 1.8 ± 0.4 (39) |
CTL, control; ISO, isoflurane at 0.58 ± 0.04 mM (∼1.9 MAC); τrecovery, half-time for recovery form inactivation; Vh, holding potential.
↵* P < 0.05 (Nav1.2 vs. Nav1.6); **P < 0.05 (CTL vs. ISO); ***P < 0.05 (Nav1.1 vs. Nav1.2).