TABLE 1

Binding and kinetic parameters of 5-HOB and formoterol for the human β2-AR

The values are expressed as mean ± S.E.M. of at least three independent experiments.

5-HOBFormoterol
Equilibrium Ki (nM)1.62 ± 0.5512.9 ± 4.3
kon (M−1min−1)7.43 ± 2.42 × 1081.78 ± 0.21 × 108
koff (min−1)0.73 ± 0.133.0 ± 0.4
Kinetic Kd (nM)1.08 ± 0.1416.80 ± 0.04
t1/2 of dissociation (s)5714