Noncompartmental analysis of blood 8E3 concentrations after a single dose of 8E3 in noninfected and AB899-infected mice
Data are presented as the mean ± S.D. (n = 5).
| Dose (mg/kg) | 8E3 Injection Route | AB899 Inoculum | Cmax | AUC0–24 h |
|---|---|---|---|---|
| CFU | µg/ml | h × µg per milliliter | ||
| 50 | Intraperitoneal | 1 × 109 | 1.16 × 102 ± 1.28 × 101 | 1.78 × 103 ± 2.77 × 102 |
| 200 | Intraperitoneal | 1 × 109 | 5.10 × 102 ± 5.81 × 101 | 8.70 × 103 ± 2.93 × 102 |
| 500 | Intraperitoneal | 1 × 109 | 1.29 × 103 ± 1.59 × 102 | 2.56 × 104 ± 2.92 × 103 |
| 200 | Intraperitoneal | Noninfected | 5.60 × 102 ± 1.16 × 102 | 8.28 × 103 ± 1.30 × 103 |
| 50 | Intravenous | 1 × 109 | 2.26 × 102 ± 1.00 × 101 | 2.43 × 103 ± 1.92 × 102 |