Unbound fractions for CCT196969, LY3009120, and MLN2480 in plasma, brain, and serum-containing cell culture media, determined by in vitro RED experiments
Data represent the mean ± S.D. (n = 3).
| Inhibitor | Matrix | %fu |
|---|---|---|
| CCT196969 | Plasma | 0.1 ± 0.01 |
| Brain | 0.50 ± 0.10 | |
| Cell culture media | 21.51 ± 1.58 | |
| LY3009120 | Plasma | 1.82 ± 0.18 |
| Brain | 0.93 ± 0.04 | |
| Cell culture media | 27.90 ± 2.13 | |
| MLN2480 | Plasma | 4.21 ± 0.16 |
| Brain | 0.98 ± 0.09 | |
| Cell culture media | 34.20 ± 1.52 |