TABLE 1

Effect of melafolone and anti-PD-1 therapy on body weight profile, biochemical profile and complete blood counts in the CMT167 tumor model

The CMT167 cells (2 × 10⁵) were injected subcutaneously into the right flank of C57BL/6 mice. Seven days later when tumors had reached a size of about 100 mm³, the mice were treated with anti-PD-1 (200 μg/mouse every 3 days, i.p.), Mel (20 mg/kg daily, i.p.), anti-PD-1 antibody (200 μg/mouse every 3 days, i.p.) plus Mel (20 mg/kg daily, i.p.), or vehicle for 14 days. The plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatine levels, creatine kinase-MB (CK-MB), and complete blood counts, including white blood corpuscles (WBC), red blood corpuscles (RBC), hematocrit (HCT), mean cell volume (MCV), and platelet (PLT) levels, were determined. Data are presented as mean ± S.E.M., n = 8.