TABLE 1

Echocardiography for CCC mice

Uninf, n = 9; CCC-Veh, n = 8; CCC-sPDNF, n = 10. Mean + S.D. is indicated for each parameter.

UninfCCC-VehCCC-sPDNF
End diastolic diameter (mm)3.637 ± 0.304.629 ± 1.03a3.489 ± 0.49b
End systolic diameter (mm)2.620 ± 0.433.233 ± 1.062.142 ± 0.55b
Anterior wall thickness (mm)0.780 ± 0.130.771 ± 0.190.776 ± 0.10
Posterior wall thickness (mm)0.879 ± 0.200.864 ± 0.270.872 ± 0.25
Heart rate (bpm)438.9 ± 52.4226.3 ± 124.2c347.8 ± 131.0
Ejection fraction (%)54.58 ± 12.2658.59 ± 11.0568.69 ± 15.06
Fractional shortening (%)28.24 ± 8.3531.20 ± 6.7239.13 ± 12.27
LV mass (mg)106.23 ± 22.57164.98 ± 89.0497.96 ± 22.54d
  • bpm, beats per minute.

  • a P < 0.05, Uninf vs. CCC-Veh.

  • b P < 0.01, CCC-Veh vs. CCC-sPDNF.

  • c P < 0.01, Uninf vs. CCC-Veh;

  • d P < 0.05, CCC-Veh vs. CCC-sPDNF.