TABLE 1

Pharmacokinetic constants for AM-2201 and its metabolites after subcutaneous administration of 0.1, 0.3, or 1.0 mg/kg AM-2201 in male rats

Data are expressed as the mean ± S.E.M. for N = 4–5 rats/group.

AnalyteAM-2201 Dose CmaxAUC Tmaxt1/2
mg/kgµg/lh/µg per literh
AM-22010.1 (N = 5)8.2 ± 1.751 ± 81.4 ± 0.24.3 ± 0.1
0.3 (N = 5)33 ± 8.9149 ± 131.3 ± 0.34.6 ± 0.3
1.0 (N = 4)42 ± 9*487 ± 74**1.3 ± 0.46.3 ± 0.8*
JWH-018 N-(5-hydroxypentyl)0.1 (N = 5)0.17 ± 0.020.71 ± 0.111.8 ± 0.2N.D.
0.3 (N = 5)0.40 ± 0.042.1 ± 0.12.0 ± 0.0N.D.
1.0 (N = 4)0.91 ± 0.08**11 ± 1**3.5 ± 1.5N.D.
JWH-018 N-pentanoic acid0.1 (N = 5)0.12 ± 0.010.77 ± 0.094.8 ± 1.3N.D.
0.3 (N = 5)0.36 ± 0.025.4 ± 0.4*6.8 ± 1.2N.D.
1.0 (N = 4)0.67 ± 0.10**12.0 ± 1.5**8.0 ± 0.8N.D.
  • N.D., not determined.

  • * P < 0.05, significant difference compared with 0.1 mg/kg dose; **P < 0.05, significant difference compared with 0.1 and 0.3 mg/kg doses.