Parameters (Unit) | Definition | Estimates (RSE%) |
---|---|---|

δ (ng⋅ml^{−1}) | Free drug concentration threshold in plasma | 40.4 (0.20) |

f_{u} | Unbound fraction | 0.015 fixed |

k (h_{efi}^{−1}) | First-order transfer rate into the effect compartment | 1 fixed |

k (h_{efo}^{−1}) | First-order transfer rate from the effect compartment | 0.202 (1.20) |

K (ng⋅ml_{d}^{−1}) | Dissociation constant from Bcl-2 | 2.76 fixed |

k (h_{in}^{−1}) | Production rate of relative caspase activity | 57.2 |

k (h_{out}^{−1}) | First-order degradation rate of caspase | 1.23 (11.6) |

I_{50} | Value of relative Bcl-2 activity for which caspase production is reduced by 50% | 0.530 (2.40) |

γ | Sigmoidicity coefficient | 5.88 (3.00) |

ε _{exp} | Multiplicative component of the residual error | 0.230 (8.00) |

RSE(%), relative standard error computed as the ratio between the S.E. and the parameter estimate multiplied by 100.