TABLE 2

 Activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) in normal (n = 74) and fibrotic livers (n = 88)

Normal Tissue (Median, Range) (nmol·min−1·mg−1 protein)Fibrotic Tissue (Median, Range) (nmol·min−1·mg−1 Protein)
Median, RangeRatioMedian, RangeRatio
ADH1.81, 0.16–72.12450.87.27, 1.18–43.07a36.5
ADHI0.44, 0.09–1.2614.01.34, 0.37–7.10a19.2
ADHII0.18, 0.03–0.5317.70.46, 0.14–1.66a11.9
ALDH0.12, 0.02–0.3216.00.15, 0.03–0.35b11.7
ADH/ALDH17.2, 1.6–1295.3809.644.61, 10.4–726.5a69.9
ADHI/ALDH3.8, 1.02–41.8841.18.96, 1.90–49.21a25.9
  • a Versus normal tissues, P < 0.001.

  • b Versus normal tissues, P < 0.01.