TABLE 5

Summary of statistical analysis of inflammatory cytokine biomarkers (PD population)

Cytokine (pg/ml)Placebo (N = 16)Nemiralisib 1000 µg (N = 16)
nPosterior Median Change from Baseline (95% CrI)nPosterior Median Change from Baseline (95% CrI)Posterior Median Nemiralisib/Placebo (95% CrI)Nemiralisib/Placebo % InhibitionPosterior Probability of True Ratio >0%
IL-515a1.06 (0.65, 1.76)15a0.88 (0.54, 1.41)0.83 (0.48, 1.42)17%78%
IL-6160.97 (0.59, 1.57)160.83 (0.49, 1.36)0.85 (0.51, 1.39)15%76%
IL-8151.01 (0.54, 1.91)160.94 (0.51, 1.73)0.92 (0.54, 1.58)8%63%
IL-13161.27 (0.90, 1.82)161.18 (0.82, 1.68)0.93 (0.61, 1.40)7%64%
TNF-α160.95 (0.57, 1.58)160.99 (0.60, 1.67)1.04 (0.62, 1.75)−4%44%
  • a Seven of 15 values for IL-5 were imputed as half the lower limit of quantification.