TABLE 4

Summary of on-treatment adverse events (safety population)

Adverse EventNumber (%) of Subjects
Placebo (N = 47)Nemiralisib 1000 ยตg (N = 48)Total (N = 50)
Total15 (32)25 (52)31 (62)
Cough4 (9)17 (35)19 (38)
Nasopharyngitis5 (11)1 (2)6 (12)
Headache3 (6)1 (2)4 (8)
Throat irritation02 (4)2 (4)
Oropharyngeal pain1 (2)1 (2)2 (4)
Rhinitis2 (4)02 (4)
Bone contusion01 (2)1 (2)
Diarrhea01 (2)1 (2)
Dysphonia01 (2)1 (2)
Dyspnoea exertional01 (2)1 (2)
Fall01 (2)1 (2)
Hand fracture01 (2)1 (2)
Hypersensitivity01 (2)1 (2)
Influenza01 (2)1 (2)
Migraine01 (2)1 (2)
Muscle strain01 (2)1 (2)
Oral herpes01 (2)1 (2)
Rash01 (2)1 (2)
Sciatica01 (2)1 (2)
Sputum increased01 (2)1 (2)
Thermal burn01 (2)1 (2)
Arthralgia1 (2)01 (2)
Back pain1 (2)01 (2)
Dizziness1 (2)01 (2)
Dyspnoea1 (2)01 (2)
Epicondylitis1 (2)01 (2)
Migraine with aura1 (2)01 (2)
Respiratory tract infection1 (2)01 (2)