Parameters (Unit) | Definition | Estimates (RSE%) | IIV% (RSE%) |
---|---|---|---|
F | Bioavailability | 0.542 (7.27) | 31.3 (40.2) |
VMA (mg⋅h−1⋅kg−1) | Maximum rate of absorption | 41.7 (14.2) | — |
KMA (mg⋅kg−1) | Drug amount corresponding to 50% of maximum rate of absorption | 11.4 (31.8) | — |
Vc (l⋅kg−1) | Volume of distribution of the central compartment | 1.18 (7.97) | 24.9 (63.9) |
Km (ng⋅ml−1) | Drug concentration corresponding to 50% of maximum rate of elimination | 654 (28.9) | 75.8 (26.1) |
Vm0 (mg⋅h−1⋅kg−1) | Maximum rate of elimination | 3.79 (13.3) | — |
k26 (h−1) | First-order distribution rate constants | 0.470 (17.1) | — |
k62 (h−1) | First-order distribution rate constants | 0.480 (8.33) | — |
kel (h−1) | First-order enzyme degradation rate constant | 0.00789 (125) | — |
Emax | Maximum capacity for enzyme production stimulation | 4.33 (66.5) | — |
E50 (ng⋅ml−1) | Drug concentration corresponding to 50% stimulation of enzyme production | 3745 (185) | — |
εmult | Multiplicative component of the residual error | 0.325 (5.75) | — |
εadd (ng⋅ml−1) | Additive component of the residual error | 0.674 (15.3) | — |
IIV%, interindividual variability expressed in percentage; RSE%, relative standard error computed as the ratio between the S.E. and the parameter estimate multiplied by 100.