TABLE 1

Hemodynamic parameters in nonviral cirrhotic rats treated with vehicle or NUCs

Values are expressed as mean ± S.E.M. All P > 0.05 among groups. Controls were treated with distilled water (vehicle).

Control (n = 6)Lamivudine (n = 5)Entecavir (n = 5)Tenofovir (n = 5)
BW (g)368 ± 20368 ± 26381 ± 17398 ± 14
MAP (mm Hg)94 ± 792 ± 389 ± 7100 ± 3
HR (beats/min)254 ± 22254 ± 8246 ± 26274 ± 6
PP (mm Hg)13.5 ± 0.815.6 ± 1.013.7 ± 2.714.6 ± 1.2
CI (ml/min per 100 g)46 ± 348 ± 537 ± 431 ± 2
SVR (mm Hg/ml per minute per 100 g)2.1 ± 0.32.0 ± 0.22.5 ± 0.53.2 ± 0.2
SMA flow (ml/min per 100 g)6.2 ± 0.77.0 ± 1.06.3 ± 0.86.1 ± 0.4
SMA resistance (mm Hg/ml per minute per 100 g)13.8 ± 2.011.5 ± 1.312.5 ± 1.714.2 ± 0.9
Hepatic flow (portal part, ml/min per 100 g)8.2 ± 1.110.6 ± 0.98.3 ± 1.27.9 ± 0.6
HVR (mm Hg/ml per minute per 100 g)1.8 ± 0.261.5 ± 0.11.8 ± 0.31.9 ± 0.2
  • HVR, hepatic vascular resistance; n, number of rats; SVR, systemic vascular resistance.