TABLE 1

Pharmacokinetic parameters for plasma and brain distribution of SRI-31142 after administration of 10 mg/kg, i.p.

ParameterBrainPlasma
Tmax10 min10 min
Cmax35.2 ng/ml (77.1 nM)1125 ng/ml (2.5 ยตM)
t1/2Not determined4.4 h
AUC18.2 h/ng per milliliter880 h/ng per milliliter
  • AUC, area under the curve; t1/2, half-life.