TABLE 1

Potency (pEC50) values obtained from concentration-response curves in esophageal rings from control, PHZ, SCD, eNOS−/−, and eNOS−/−-PHZ mice

Concentration-response curves for CCh (10 nM to 100 μM) and KCl (1 mM to 1 M) in the absence and in the presence of either SNP (300 μM) or BAY 41-2272 (BAY; 1 μM). Data represent the mean ± S.E.M. of five experiments.

pEC50
ControlPHZSCD
CCh5.78 ± 0.056.00 ± 0.055.92 ± 0.09
CCh/SNP5.81 ± 0.085.91 ± 0.05n.d.
CCH/BAY5.74 ± 0.055.88 ± 0.07n.d.
KCl1.41 ± 0.041.52 ± 0.021.15 ± 0.12
KCl/SNP1.33 ± 0.031.41 ± 0.05n.d.
KCl/BAY1.13 ± 0.081.43 ± 0.11n.d.
  • n.d., not determined.